Membrane traffic in the secretory pathway: Regulation of secretory vesicle traffic by Rab small GTPases

Research output: Contribution to journalReview article

264 Citations (Scopus)

Abstract

Secretion is a fundamental biological activity of all eukaryotic cells by which they release certain substances in the extracellular space. It is considered a specialized mode of membrane trafficking that is achieved by docking and fusion of secretory vesicles to the plasma membrane (i.e., exocytosis). Secretory vesicle traffic is thought to be regulated by a family of Rab small GTPases, which are regulators of membrane traffic that are common to all eukaryotic cells. Classically, mammalian Rab3 subfamily members were thought to be critical regulators of secretory vesicle exocytosis in neurons and endocrine cells, but recent genetic and proteomic studies indicate that Rab3 is not the sole Rab isoform that regulates secretory vesicle traffic. Rather, additional Rab isoforms, especially Rab27 subfamily members, are required for this process. In this article I review the current literature on the function of Rab isoforms and their effectors in regulated secretory vesicle traffic. (Part of a Multi-author Review).

Original languageEnglish
Pages (from-to)2801-2813
Number of pages13
JournalCellular and Molecular Life Sciences
Volume65
Issue number18
DOIs
Publication statusPublished - 2008 Sep 1

Keywords

  • Docking
  • Exocytosis
  • Rab effector
  • Rab27
  • Rab3
  • Rabphilin
  • Secretory vesicle
  • Synaptotagmin-like protein

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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