Melastatin transient receptor potential channel type 5

Minoru Wakamori, Takashi Yoshida, Takashi Kikuchi, Daisuke Kondoh, Masashi Komatsu

Research output: Chapter in Book/Report/Conference proceedingChapter


Fat is one of the three major nutrients but it is not a sapid substance which activates one of the five basic tastes, sweet, bitter, sour, salt, and umami. However, we have experience that fat changes the taste of dishes largely. Transient receptor potential M5 (TRPM5) channel is not a receptor of the five basic tastes but it is gated after stimulation of the gustducin-coupled receptors for sweet, bitter, and umami. TRPM5 channel is a cation channel and depolarizes the taste cell, indicating that TRPM5 channel relates to the formation of tastes. The activities of some TRP channels (TRPV2, TRPV4, TRPM2, and TRPA1 channels) are regulated by lipids. I will review the TRP channels and taste transduction.

Original languageEnglish
Title of host publicationInterface Oral Health Science 2011
PublisherSpringer Japan
Number of pages5
ISBN (Electronic)9784431540700
ISBN (Print)9784431540694
Publication statusPublished - 2012 Jan 1


  • Channel
  • TRP
  • Taste bud
  • Transient receptor potential

ASJC Scopus subject areas

  • Dentistry(all)


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