Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: Case report

Shunsuke Omodaka, Ryuta Saito, Toshihiro Kumabe, Jun Kawagishi, Hidefumi Jokura, Yukihiko Sonoda, Mika Watanabe, Takamasa Kayama, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We describe a rare case of melanotic neuroectodermal tumor (MNT) of the brain recurring 12 years after complete remission. An 11-year-old girl initially presented with exotropia and bilateral papilledema. Magnetic resonance (MR) imaging revealed an intracranial extraaxial large tumor at the midfrontal region. T1-weighted MR imaging showed the tumor to be well delineated with homogeneous enhancement by gadolinium. The tumor was subtotally removed, and the histological diagnosis was MNT. The residual tumor became enlarged, so gamma knife radiosurgery was performed 5 months after initial surgery. The enhanced lesion disappeared, but another lesion emerged 3 years later. A second gamma knife radiosurgery was performed for this local recurrence. The enhanced lesion disappeared once again. Twelve years after the second gamma knife radiosurgery, another local recurrence was detected. This tumor was subtotally removed. Histological examination confi rmed the same diagnosis of MNT. This case suggests that MNTs not completely resected need long-term follow up, even if complete remission was achieved after adjuvant therapy.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalBrain Tumor Pathology
Volume27
Issue number1
DOIs
Publication statusPublished - 2010 Apr

Keywords

  • Gamma knife
  • Melanotic neuroectodermal tumor of the brain
  • Prognosis
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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