Medical procedures and risk for sporadic creutzfeldt-jakob disease, Japan, 1999-2008

Tsuyoshi Hamaguchi, Moeko Noguchi-Shinohara, Ichiro Nozaki, Yosikazu Nakamura, Takeshi Sato, Tetsuyuki Kitamoto, Hidehiro Mizusawa, Masahito Yamada

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To elucidate the association between medical procedures and sporadic Creutzfeldt-Jakob disease (sCJD), we analyzed medical procedures (any surgical procedure, neu- rosurgery, ophthalmic surgery, and blood transfusion) for patients registered by the CJD Surveillance Committee in Japan during 1999-2008. We conducted an age-stratified case-control study with 753 sCJD patients and 210 controls and a study of patients who underwent neurosurgical or ophthalmic surgical procedures at the same hospital. Although the control group was relatively small, no evidence was found that prion disease was transmitted through the investigated medical procedures before onset of sCJD. After onset of sCJD, 4.5% of the sCJD patients underwent operations, including neurosurgical for 0.8% and ophthalmic for 1.9%; no special precautions against transmission of prion diseases were taken. Fortunately, we have not identified patients with prion disease attributed to these operations. Our findings indicate that surgical procedures or blood transfusion had little effect on the incidence of sCJD.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalEmerging Infectious Diseases
Volume15
Issue number2
DOIs
Publication statusPublished - 2009 Feb

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    Hamaguchi, T., Noguchi-Shinohara, M., Nozaki, I., Nakamura, Y., Sato, T., Kitamoto, T., Mizusawa, H., & Yamada, M. (2009). Medical procedures and risk for sporadic creutzfeldt-jakob disease, Japan, 1999-2008. Emerging Infectious Diseases, 15(2), 265-271. https://doi.org/10.3201/eid1502.080749