Mechanotransduction and mechanical control of gene expression

Kota Miyasaka, Atsushi Kubo, Toshihiko Ogura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cells change gene expression when they differentiate into different cell lineages. Cells also change their gene expression profiles to adapt to altering milieus. Even physical forces(for example, forces evoked by muscle contraction or exercise)change gene expression dramatically, although the molecular mechanisms of this physico-genetic link are largely unknown. Here, we summarize several works published recently, trying to highlight the physical force as an essential parameter of gene expression and maintenance of homeostasis.

Original languageEnglish
Pages (from-to)1729-1736
Number of pages8
JournalClinical calcium
Volume26
Issue number12
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Medicine(all)

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