Mechanistic studies by sum-frequency generation spectroscopy: Hydrolysis of a supported phospholipid bilayer by phospholipase A2

Yujin Tong, Na Li, Huijin Liu, Aimin Ge, Masatoshi Osawa, Shen Ye

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

(Figure Presented) Sum mothers do 'ave 'em: Sum-frequency generation spectroscopy was used to investigate the hydrolysis mechanism of a dipalmitoylphosphatidylcholine bilayer by phospholipase A2 (PLA 2). This study describes the structural changes and the hydrolysis mechanism in each leaflet (red and black) of a supported lipid bilayer at a molecular level.

Original languageEnglish
Pages (from-to)2319-2323
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number13
DOIs
Publication statusPublished - 2010 Mar 22
Externally publishedYes

Keywords

  • Hydrolysis
  • Lipid bilayers
  • Phospholipase A
  • SFG spectroscopy
  • Structure elucidation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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