Mechanisms of reconsolidation and extinction of fear memory

Satoshi Kida, Hotaka Fukushima, Nori Mamiya

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Reconsolidation and extinction of fear memories are induced by re-exposure to the conditioned stimulus (CS) but they appear to be opposite processes; as the fear memory is maintained or inhibited through reconsolidation and extinction, respectively. More importantly, reconsolidation and extinction are thought to be potential targets for the treatment of Post Traumatic Stress Disorder (PTSD). From this view, it is important to understand mechanisms by which reactivated fear memories are reconsolidated or extinguished. Here, we review processes for fear memory regulation including consolidation, reconsolidation and extinction, and discuss implications of fear memory regulation with PTSD.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalJapanese Journal of Neuropsychopharmacology
Volume29
Issue number3
Publication statusPublished - 2009 Jun 1

Keywords

  • Consolidation
  • Extinction
  • Fear memory
  • PTSD
  • Reconsolidation

ASJC Scopus subject areas

  • Clinical Psychology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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