Mechanisms of leukocyte trafficking in allergic diseases: Insights into new therapies targeting chemokines and chemokine receptors

Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Cho Cho Aye, Dai Miyazaki, Santa Jeremy Ono

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Marked inflammatory infiltration by activated leukocytes; is a characteristic feature of allergic diseases. Elucidation of the mechanisms of leukocyte trafficking in allergic diseases would identity targets to establish novel anti-inflammatory strategies for treatment of these diseases. Leukocyte trafficking is controlled by tissue-specific expression of chemokines and chemokine receptor expression on the leukocyte, surface. Here, we review the role of chemokines and their receptors in leukocyte trafficking to inflammatory sites in allergic diseases and discuss therapeutic strategies targeting chemokine networks for treatment of these diseases.

Original languageEnglish
Pages (from-to)351-364
Number of pages14
JournalExpert Review of Clinical Immunology
Volume3
Issue number3
DOIs
Publication statusPublished - 2007 May 1
Externally publishedYes

Keywords

  • Allergic disease
  • Chemokine
  • Chemokine receptor
  • Leukocyte trafficking

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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