Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases

Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Mounir Belkouch, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac

Research output: Contribution to journalShort surveypeer-review

26 Citations (Scopus)

Abstract

Docosahexaenoic acid (DHA; 22:6 ω-3) is highly enriched in the brain and is required for proper brain development and function. Its deficiency has been shown to be linked with the emergence of neurological diseases. Dietary ω-3 fatty acid supplements including DHA have been suggested to improve neuronal development and enhance cognitive functions. However, mechanisms of DHA incorporation in the brain remain to be fully understood. Findings suggested that DHA is better incorporated when esterified within lysophospholipid rather than under its non-esterified form. Furthermore, DHA has the potential to be converted into diverse oxylipins with potential neuroprotective effects. Since DHA is poorly synthesized de novo, targeting the brain with specific carriers of DHA might provide novel therapeutic approaches to neurodegenerative diseases.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalBiochimie
Volume130
DOIs
Publication statusPublished - 2016 Nov 1

Keywords

  • Blood-brain-barrier
  • Brain
  • Docosahexaenoic acid
  • Neuroprotection
  • Phospholipids
  • Transport

ASJC Scopus subject areas

  • Biochemistry

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