Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS

Hiroshi Maeda, Tomohiro Sawa, Toshimitsu Konno

Research output: Contribution to journalArticlepeer-review

734 Citations (Scopus)

Abstract

This review article describes three aspects of polymeric drugs. The general mechanism of the EPR (enhanced permeability and retention) effect and factors involved in the effect are discussed, in view of the advantages of macromolecular therapeutics for cancer treatment, which are based on the highly selective EPR-related delivery of drug to tumor. Also described are advantages of more general water-soluble polymeric drugs as primary anticancer agents, using SMANCS as an example. Last, SMANCS/Lipiodol is discussed with reference to the type of formulation for arterial injection with most pronounced tumor selective delivery, as well as its advantages, precautions, and side effects from the clinical standpoint.

Original languageEnglish
Pages (from-to)47-61
Number of pages15
JournalJournal of Controlled Release
Volume74
Issue number1-3
DOIs
Publication statusPublished - 2001 Jul 6

Keywords

  • Clinical overview
  • EPR effect
  • SMANCS

ASJC Scopus subject areas

  • Pharmaceutical Science

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