Mechanism of plasma glutathione peroxidase production in bovine adipocytes

Tadashi Yamasaki; Koji Tahara; Shoichi Takano; Miho Inoue-Murayama; Michael T. Rose; Takeshi Minashima; Hisashi Aso; Shin'ichi Ito

doi:10.1007/s00441-006-0194-4

Mechanism of plasma glutathione peroxidase production in bovine adipocytes

Tadashi Yamasaki, Koji Tahara, Shoichi Takano, Miho Inoue-Murayama, Michael T. Rose, Takeshi Minashima, Hisashi Aso, Shin'ichi Ito

AGR - Life Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are expressed following adipocyte differentiation in a bovine intramuscular preadipocyte (BIP) line. Therefore, we have analyzed the mechanism of production of pGPx in adipocytes. The expression of pGPx and C/EBPδ increases during adipogenesis, with dexamethasone being the main effector of these genes. The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells. The production of pGPx in bovine tissues is greatest in kidney and in intraperitoneal fat. We consider that the transcriptional control of pGPx in cattle might be carried out by C/EBPδ and that the expression of pGPx might be a characteristic phenomenon of bovine adipogenesis.

Original language	English
Pages (from-to)	139-147
Number of pages	9
Journal	Cell and Tissue Research
Volume	326
Issue number	1
DOIs	https://doi.org/10.1007/s00441-006-0194-4
Publication status	Published - 2006 Oct

Keywords

Adipocyte
BIP cell
Bovine
C/EBPδ
pGPx

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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title = "Mechanism of plasma glutathione peroxidase production in bovine adipocytes",

abstract = "Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are expressed following adipocyte differentiation in a bovine intramuscular preadipocyte (BIP) line. Therefore, we have analyzed the mechanism of production of pGPx in adipocytes. The expression of pGPx and C/EBPδ increases during adipogenesis, with dexamethasone being the main effector of these genes. The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells. The production of pGPx in bovine tissues is greatest in kidney and in intraperitoneal fat. We consider that the transcriptional control of pGPx in cattle might be carried out by C/EBPδ and that the expression of pGPx might be a characteristic phenomenon of bovine adipogenesis.",

keywords = "Adipocyte, BIP cell, Bovine, C/EBPδ, pGPx",

author = "Tadashi Yamasaki and Koji Tahara and Shoichi Takano and Miho Inoue-Murayama and Rose, {Michael T.} and Takeshi Minashima and Hisashi Aso and Shin'ichi Ito",

note = "Funding Information: This study was supported by a Grant-in-Aid for Scientific Research (B17380165) from the Japan Society for the Promotion of Science (JSPS) and a grant (13–365) from the Japan Livestock Technology Association. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = oct,

doi = "10.1007/s00441-006-0194-4",

language = "English",

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AU - Yamasaki, Tadashi

AU - Tahara, Koji

AU - Takano, Shoichi

AU - Inoue-Murayama, Miho

AU - Rose, Michael T.

AU - Minashima, Takeshi

AU - Aso, Hisashi

AU - Ito, Shin'ichi

N1 - Funding Information: This study was supported by a Grant-in-Aid for Scientific Research (B17380165) from the Japan Society for the Promotion of Science (JSPS) and a grant (13–365) from the Japan Livestock Technology Association. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/10

Y1 - 2006/10

N2 - Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are expressed following adipocyte differentiation in a bovine intramuscular preadipocyte (BIP) line. Therefore, we have analyzed the mechanism of production of pGPx in adipocytes. The expression of pGPx and C/EBPδ increases during adipogenesis, with dexamethasone being the main effector of these genes. The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells. The production of pGPx in bovine tissues is greatest in kidney and in intraperitoneal fat. We consider that the transcriptional control of pGPx in cattle might be carried out by C/EBPδ and that the expression of pGPx might be a characteristic phenomenon of bovine adipogenesis.

AB - Plasma glutathione peroxidase (pGPx) is an anti-oxidative enzyme. Using the polymerase chain reaction subtraction method, we have previously identified pGPx as a large part of the genes that are expressed following adipocyte differentiation in a bovine intramuscular preadipocyte (BIP) line. Therefore, we have analyzed the mechanism of production of pGPx in adipocytes. The expression of pGPx and C/EBPδ increases during adipogenesis, with dexamethasone being the main effector of these genes. The expression of pGPx gene has been clearly detected in BIP cells and human adipocytes, but hardly in 3T3-L1 cells. The production of pGPx in bovine tissues is greatest in kidney and in intraperitoneal fat. We consider that the transcriptional control of pGPx in cattle might be carried out by C/EBPδ and that the expression of pGPx might be a characteristic phenomenon of bovine adipogenesis.

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Mechanism of plasma glutathione peroxidase production in bovine adipocytes

Abstract

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