Mechanism of Macrophage Fungicidal Activity Against Cryptococcus neoformans: A Comparative Study Between Mouse and Human

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Abstract

Host defense against infection with Cryptococcus neoformans is mediated by cellular immunity and macrophages play a central role in the elimination of organisms. To acquire effective microbicidal activity, macrophages need to be stimulated by interferon (IFN)-γ, which is produced by NK cells, γ T cells and helper T cells. There are two major systems, reactive oxygen and nitrogen reactive intermediates, in the macrophage killing of microbial pathogens. This review focuses on the roles of these mediators in cryptococcocidal activity of macrophages and compares mouse and human macrophages by describing our experimental results.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalJapanese Journal of Medical Mycology
Volume38
Issue number3
DOIs
Publication statusPublished - 1997

Keywords

  • Cryptococcus neoformans
  • human
  • macrophages
  • mouse
  • nitric oxide
  • superoxide

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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