Mechanism of Macrophage Fungicidal Activity Against Cryptococcus neoformans: A Comparative Study Between Mouse and Human

Kazuyoshi Kawakami

doi:10.3314/jjmm.38.233

Mechanism of Macrophage Fungicidal Activity Against Cryptococcus neoformans: A Comparative Study Between Mouse and Human

Research output: Contribution to journal › Article › peer-review

Abstract

Host defense against infection with Cryptococcus neoformans is mediated by cellular immunity and macrophages play a central role in the elimination of organisms. To acquire effective microbicidal activity, macrophages need to be stimulated by interferon (IFN)-γ, which is produced by NK cells, γ T cells and helper T cells. There are two major systems, reactive oxygen and nitrogen reactive intermediates, in the macrophage killing of microbial pathogens. This review focuses on the roles of these mediators in cryptococcocidal activity of macrophages and compares mouse and human macrophages by describing our experimental results.

Original language	English
Pages (from-to)	233-238
Number of pages	6
Journal	Japanese Journal of Medical Mycology
Volume	38
Issue number	3
DOIs	https://doi.org/10.3314/jjmm.38.233
Publication status	Published - 1997
Externally published	Yes

Keywords

Cryptococcus neoformans
human
macrophages
mouse
nitric oxide
superoxide

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3314/jjmm.38.233

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abstract = "Host defense against infection with Cryptococcus neoformans is mediated by cellular immunity and macrophages play a central role in the elimination of organisms. To acquire effective microbicidal activity, macrophages need to be stimulated by interferon (IFN)-γ, which is produced by NK cells, γ T cells and helper T cells. There are two major systems, reactive oxygen and nitrogen reactive intermediates, in the macrophage killing of microbial pathogens. This review focuses on the roles of these mediators in cryptococcocidal activity of macrophages and compares mouse and human macrophages by describing our experimental results.",

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AB - Host defense against infection with Cryptococcus neoformans is mediated by cellular immunity and macrophages play a central role in the elimination of organisms. To acquire effective microbicidal activity, macrophages need to be stimulated by interferon (IFN)-γ, which is produced by NK cells, γ T cells and helper T cells. There are two major systems, reactive oxygen and nitrogen reactive intermediates, in the macrophage killing of microbial pathogens. This review focuses on the roles of these mediators in cryptococcocidal activity of macrophages and compares mouse and human macrophages by describing our experimental results.

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KW - macrophages

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KW - nitric oxide

KW - superoxide

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Mechanism of Macrophage Fungicidal Activity Against Cryptococcus neoformans: A Comparative Study Between Mouse and Human

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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