Abstract
This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.
Original language | English |
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Pages (from-to) | 364-367 |
Number of pages | 4 |
Journal | Chemicke Listy |
Volume | 108 |
Issue number | 4 |
Publication status | Published - 2014 Jan 1 |
Keywords
- Base excision repair
- N-pyramidalization
- Theoretical modelling
- hOGG1
ASJC Scopus subject areas
- Chemistry(all)