Mechanism of base excision with the hOGG1 DNA repair enzyme

Jakub Šebera, Lukáš Trantírek, Jiří Fukal, Yoshiyuki Tanaka, Vladimír Sychrovský

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalChemicke Listy
Volume108
Issue number4
Publication statusPublished - 2014 Jan 1

Keywords

  • Base excision repair
  • N-pyramidalization
  • Theoretical modelling
  • hOGG1

ASJC Scopus subject areas

  • Chemistry(all)

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