Mechanism of base excision with the hOGG1 DNA repair enzyme

Jakub Šebera; Lukáš Trantírek; Jiří Fukal; Yoshiyuki Tanaka; Vladimír Sychrovský

Mechanism of base excision with the hOGG1 DNA repair enzyme

Jakub Šebera, Lukáš Trantírek, Jiří Fukal, Yoshiyuki Tanaka, Vladimír Sychrovský

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Chemicke Listy
Volume	108
Issue number	4
Publication status	Published - 2014 Jan 1

Keywords

Base excision repair
N-pyramidalization
Theoretical modelling
hOGG1

ASJC Scopus subject areas

Chemistry(all)

Cite this

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title = "Mechanism of base excision with the hOGG1 DNA repair enzyme",

abstract = "This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.",

keywords = "Base excision repair, N-pyramidalization, Theoretical modelling, hOGG1",

author = "Jakub {\v S}ebera and Luk{\'a}{\v s} Trant{\'i}rek and Ji{\v r}{\'i} Fukal and Yoshiyuki Tanaka and Vladim{\'i}r Sychrovsk{\'y}",

year = "2014",

month = jan,

day = "1",

language = "English",

volume = "108",

pages = "364--367",

journal = "Chemicke Listy",

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publisher = "Czech Society of Chemical Engineering",

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TY - JOUR

T1 - Mechanism of base excision with the hOGG1 DNA repair enzyme

AU - Šebera, Jakub

AU - Trantírek, Lukáš

AU - Fukal, Jiří

AU - Tanaka, Yoshiyuki

AU - Sychrovský, Vladimír

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

AB - This article suggests a new mechanistic scheme of the catalytic 8-oxoguanine excision with the hOGG1 base excision repair protein. The energy-efficient and substratespecific scheme employs enforced pyramidalization of the glycosidic nitrogen in the nucleobase within the hOGG1 catalytic pocket.

KW - Base excision repair

KW - N-pyramidalization

KW - Theoretical modelling

KW - hOGG1

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UR - http://www.scopus.com/inward/citedby.url?scp=84899727877&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84899727877

VL - 108

SP - 364

EP - 367

JO - Chemicke Listy

JF - Chemicke Listy

SN - 0009-2770

IS - 4

ER -

Mechanism of base excision with the hOGG1 DNA repair enzyme

Abstract

Keywords

ASJC Scopus subject areas

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