Mechanical regulation of macrophage function - Cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages

Kentaro Maruyama, Eiji Nemoto, Satoru Yamada

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Mechanical stress maintains tissue homeostasis by regulating many cellular functions including cell proliferation, differentiation, and inflammation and immune responses. In inflammatory microenvironments, macrophages in mechanosensitive tissues receive mechanical signals that regulate various cellular functions and inflammatory responses. Macrophage function is affected by several types of mechanical stress, but the mechanisms by which mechanical signals influence macrophage function in inflammation, such as the regulation of interleukin-1β by inflammasomes, remain unclear. In this review, we describe the role of mechanical stress in macrophage and monocyte cell function.

Original languageEnglish
Article number3
JournalInflammation and Regeneration
Volume39
Issue number1
DOIs
Publication statusPublished - 2019 Feb 7

Keywords

  • Cyclic stretch
  • Inflammasome
  • Macrophage
  • Mechanical stress

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Cell Biology

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