Measurement of histamine release change in living human brain associated with stress and circadian rhythm

Katsuhiko Shibuya, Manabu Tashiro, Shoichi Watanuki, Md Mehedi Masud, Masayasu Miyake, Kazuaki Kumagai, Yoichi Ishikawa, Ren Iwata, Kazuhiko Yanai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Nowadays, the neural receptor study has been reported in many research papers. Human studies related with neural receptors have made progress by the technological improvement of positron emission tomography (PET) and development of various radiopharmaceuticals that can specifically bind to neuroreceptors. A previous study by Koepp et al. revealed, in 1998, that the release of neuronal dopamine had been increased in human brain during performing a "goal-directed task" (video game). Given an idea from this previous study, we hypothesized that the release of histamine, another neurotransmitter in the brain, might change under the influence of physiological factors such as stress and circadian rhythm. The purpose of our present study was to evaluate the change of brain histamine release induced by stress and circadian rhythm in the healthy human subjects by using [11C]doxepin and PET method. In results, there was a trend for decreased BP in the condition of calculation task, but the difference was not significant, demonstrating that the histamine release in the brain would not be influenced so much by psychological stress. However, the BP was higher in the morning than in the afternoon. The result indicates that histamine release in human brain would be higher in the afternoon than in the morning.

Original languageEnglish
Title of host publication6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
Pages1644-1647
Number of pages4
DOIs
Publication statusPublished - 2010
Event6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech - Singapore, Singapore
Duration: 2010 Aug 12010 Aug 6

Publication series

NameIFMBE Proceedings
Volume31 IFMBE
ISSN (Print)1680-0737

Other

Other6th World Congress of Biomechanics, WCB 2010 - In Conjunction with 14th International Conference on Biomedical Engineering, ICBME and 5th Asia Pacific Conference on Biomechanics, APBiomech
CountrySingapore
CitySingapore
Period10/8/110/8/6

Keywords

  • Histamine
  • binding potential (BP)
  • neural receptor
  • positron emission tomography (PET)
  • stress

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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