Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using [11C]diprenorphine and positron emission tomography

Anthony K.P. Jones, Niel D. Kitchen, Hiroshi Watabe, Vincent J. Cunningham, Terry Jones, Savinda K. Luthra, David G.T. Thomas

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

The binding of [11C]diprenorphine to μ, K, and subsites in cortical and subcortical structures was measured by positron emission tomography in vivo in six patients before and after surgical relief of trigeminal neuralgia pain. The volume of distribution of [11C]diprenorphine binding was significantly increased after thermocoagulation of the relevant trigeminal division in the following areas: prefrontal, insular, perigenual, mid- cingulate and inferior parietal cortices, basal ganglia, and thalamus bilaterally. In addition to the pain relief associated with the surgical procedure, there also was an improvement in anxiety and depression scores. In the context of other studies, these changes in binding most likely resulted from the change in the pain state. The results suggest an increased occupancy by endogenous opioid peptides during trigeminal pain but cannot exclude coexistent down-regulation of binding sites.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number7
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Brain
  • Opiate receptors
  • Pain
  • Positron emission tomography
  • Trigeminal neuralgia
  • [C]Diprenorphine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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