Maximum wall shear at the nuclear bulge of endothelial cells and their alignment along the blood flow - a computational fluid mechanical study

Takami Yamaguchi

Research output: Contribution to conferencePaperpeer-review

1 Citation (Scopus)

Abstract

The mechanism of arterial endothelial cell deformation and alignment was studied using a three dimensional computational fluid mechanical model of the arteriolar wall with regularly arranged intraluminal undulation simulating the endothelial cells. Endothelial cells were simulated using a 2D Gaussian distribution function, which had three parameters used to define the shape of the cells. They were the elongation factor, which is the correlation coefficient of the Gaussian distribution function, the height of the cells, and the cellular angle against the blood flow. The Navier Stokes equations of the Newtonian fluid with steady flow conditions were solved using a finite volume method and the absolute wall shear stress(WSS) at the summit of the cells was calculated. The WSS at the nuclear bulge varied in a complex manner and the hypothesis that the endothelial cells change their shape and alignment to minimize the WSS at the nuclear bulge was shown to explain the computed results.

Original languageEnglish
Pages347-348
Number of pages2
Publication statusPublished - 1994 Dec 1
EventProceedings of the 1994 International Mechanical Engineering Congress and Exposition - Chicago, IL, USA
Duration: 1994 Nov 61994 Nov 11

Other

OtherProceedings of the 1994 International Mechanical Engineering Congress and Exposition
CityChicago, IL, USA
Period94/11/694/11/11

ASJC Scopus subject areas

  • Engineering(all)

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