Matrix therapies for cell support and cardiac repair

Kay Maeda, Rashmi Tiwari-Pandey, Marc Ruel, Erik J. Suuronen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Cardiac disease is one of the most common causes of death in the world. Currently, surgically invasive therapies, such as implantable devices and, ultimately, heart transplantation, are the only remedies for end-stage congestive heart disease, which constitutes the final common pathway for all cardiac disorders. However, these surgical treatments are all mechanical and do not repair the damaged heart tissue. On the other hand, regenerative therapy promises to revolutionize the treatment of these patients and provides a biological and natural solution for cardiac repair. For example, biomaterials for the delivery of cells, growth factors and/or signaling molecules have been developed to treat the diseased heart. Biomaterials can provide suitable microenvironments to promote angiogenesis, deliver several key signals needed for repair processes, enhance engraftment and differentiation of cells, and modify cell function in different ways. Biomaterials can mimic the natural extracellular matrix, which supports the structure and functions of cells. Over the last decade, many biomaterials have been developed and used. In this chapter, we provide an overview of the biomaterials most commonly used for cardiac tissue engineering in preclinical studies and discuss their roles in cardiac repair processes.

Original languageEnglish
Title of host publicationBiomaterials for Cardiac Regeneration
PublisherSpringer International Publishing
Pages117-158
Number of pages42
ISBN (Electronic)9783319109725
ISBN (Print)9783319109718
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Medicine(all)

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