Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back

Hiromu Chiba; Yumi Kambayashi; Erika Tamabuchi; Akira Hashimoto; Taku Fujimura

doi:10.1159/000520971

Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back

Hiromu Chiba, Yumi Kambayashi, Erika Tamabuchi, Akira Hashimoto, Taku Fujimura

Research output: Contribution to journal › Article › peer-review

Abstract

Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.

Original language	English
Pages (from-to)	1773-1778
Number of pages	6
Journal	Case Reports in Oncology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1159/000520971
Publication status	Published - 2021 Dec 13
Externally published	Yes

Keywords

Local recurrence
Matrix metalloproteinase 28
Microcystic adnexal carcinoma
Nerve infiltration
Radiation resistant

ASJC Scopus subject areas

Oncology

Access to Document

10.1159/000520971

Cite this

@article{5ba0589c48d745c4bab99f85c4544bbb,

title = "Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back",

abstract = "Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.",

keywords = "Local recurrence, Matrix metalloproteinase 28, Microcystic adnexal carcinoma, Nerve infiltration, Radiation resistant",

author = "Hiromu Chiba and Yumi Kambayashi and Erika Tamabuchi and Akira Hashimoto and Taku Fujimura",

note = "Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (21ym0126041h0001). Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by S. Karger AG, Basel",

year = "2021",

month = dec,

day = "13",

doi = "10.1159/000520971",

language = "English",

volume = "14",

pages = "1773--1778",

journal = "Case Reports in Oncology",

issn = "1662-6575",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back

AU - Chiba, Hiromu

AU - Kambayashi, Yumi

AU - Tamabuchi, Erika

AU - Hashimoto, Akira

AU - Fujimura, Taku

N1 - Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (21ym0126041h0001). Publisher Copyright: © 2021 The Author(s). Published by S. Karger AG, Basel

PY - 2021/12/13

Y1 - 2021/12/13

N2 - Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.

AB - Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.

KW - Local recurrence

KW - Matrix metalloproteinase 28

KW - Microcystic adnexal carcinoma

KW - Nerve infiltration

KW - Radiation resistant

UR - http://www.scopus.com/inward/record.url?scp=85121441532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85121441532&partnerID=8YFLogxK

U2 - 10.1159/000520971

DO - 10.1159/000520971

M3 - Article

AN - SCOPUS:85121441532

SN - 1662-6575

VL - 14

SP - 1773

EP - 1778

JO - Case Reports in Oncology

JF - Case Reports in Oncology

IS - 3

ER -

Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this