TY - JOUR
T1 - Maternal Baseline Characteristics and Perinatal Outcomes
T2 - The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
AU - Sugawara, Junichi
AU - Ishikuro, Mami
AU - Obara, Taku
AU - Onuma, Tomomi
AU - Murakami, Keiko
AU - Kikuya, Masahiro
AU - Ueno, Fumihiko
AU - Noda, Aoi
AU - Mizuno, Satoshi
AU - Kobayashi, Tomoko
AU - Hamanaka, Yohei
AU - Suzuki, Kichiya
AU - Kodama, Eiichi
AU - Tsuchiya, Naho
AU - Uruno, Akira
AU - Suzuki, Yoichi
AU - Tanabe, Osamu
AU - Kiyomoto, Hideyasu
AU - Tsuboi, Akito
AU - Shimizu, Atsushi
AU - Koshiba, Seizo
AU - Minegishi, Naoko
AU - Ogishima, Soichi
AU - Tamiya, Gen
AU - Metoki, Hirohito
AU - Hozawa, Atsushi
AU - Fuse, Nobuo
AU - Kinoshita, Kengo
AU - Kure, Shigeo
AU - Yaegashi, Nobuo
AU - Kuriyama, Shinichi
AU - Yamamoto, Masayuki
N1 - Funding Information:
Funding: The TMM is supported by grants from the Reconstruction Agency; from the Ministry of Education, Culture, Sports, Science and Technology; and the Japan Agency for Medical Research and Development (AMED). This study was supported by AMED under grant numbers JP19km0105001, JP19km0105002. Conflicts of interest: None declared.
Publisher Copyright:
© 2020 Junichi Sugawara et al.
PY - 2022
Y1 - 2022
N2 - Background: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. Methods: Expectant mothers living in Miyagi Prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. Results: A total of 23,406 pregnancies involving 23,730 fetuses resulted in 23,143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes, and hypertensive disorders of pregnancy. Conclusions: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.
AB - Background: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study was launched in 2013 to evaluate the complex interactions of genetic and environmental factors in multifactorial diseases. The present study describes the maternal baseline profile and perinatal data of participating mothers and infants. Methods: Expectant mothers living in Miyagi Prefecture were recruited from obstetric facilities or affiliated centers between 2013 and 2017. Three sets of self-administered questionnaires were collected, and the medical records were reviewed to obtain precise information about each antenatal visit and each delivery. Biospecimens, including blood, urine, umbilical cord blood, and breast milk, were collected for the study biobank. The baseline maternal sociodemographic characteristics, results of screening tests, and obstetric outcomes were analyzed according to the maternal age group. Results: A total of 23,406 pregnancies involving 23,730 fetuses resulted in 23,143 live births. Younger maternal participants had a tendency toward a higher incidence of threatened abortion and threatened premature labor, while older age groups exhibited a significantly higher rate of low lying placenta, placenta previa, gestational diabetes, and hypertensive disorders of pregnancy. Conclusions: The present study clearly shows the distribution of maternal baseline characteristics and the range of perinatal outcomes according to maternal age group. This cohort study can provide strategic information for creating breakthroughs in the pathophysiology of perinatal, developmental, and noncommunicable diseases by collaborative data visiting or sharing.
KW - Baseline profile
KW - Birth cohort
KW - Developmental origins of health and disease
KW - Perinatal outcome
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U2 - 10.2188/jea.JE20200338
DO - 10.2188/jea.JE20200338
M3 - Article
C2 - 33041318
AN - SCOPUS:85108278000
SN - 0917-5040
VL - 32
SP - 69
EP - 79
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 2
ER -
