Mast cells inhibit CD8 + T cell-mediated rejection of a malignant fibrous histiocytoma-like tumor: Involvement of Fas-Fas Ligand axis

Hiroshi Furukawa, Hiroshi Kitazawa, Izumi Kaneko, Koichi Kikuchi, Shigeto Tohma, Masato Nose, Masao Ono

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Problem statement: Mast cells develop from bone marrow-derived progenitor cells and are distributed in the skin or mucosa where they play proinflammatory roles in the first line of defense. Since some tumors in humans and experimental animals exhibited infiltration of increased mast cells, we investigated the contribution of mast cells to the override of tumor rejection. Approach: MRL/N-1 cells are malignant fibrous histiocytoma-like cells established from the spleen of a Fas ligand (FasL)- deficient MRL/Mp-FasL gld/gld (MRL/gld) mouse and are implantable in Fas-deficient MRL/Mp-Fas lpr/lpr (MRL/lpr) mice. MRL/N-1 cells were implanted in MRL/gld, MRL/lpr and MRL/+mice after antibody treatments or with mast cells or macrophages and the tumor growth was observed. Results: MRL/N-1 cells were rejected by Fas-intact syngeneic MRL/+ mice in CD8+ T cell-mediated manner. This rejection was inhibited by the co-implanted mast cells. MRL/N-1 cells transfected with FasL were rejected by MRL/+ and MRL/gld mice. Conclusion: Mast cells abrogate the rejection of MRL/N-1 tumor cells and that this tumor rejection is mediated by CD8+ T cells and dependent on host Fas-FasL axis.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalAmerican Journal of Immunology
Volume5
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • Fas
  • Fasl
  • Mast cell
  • Syngeneic tumor rejection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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