Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice

Yasushi Ishijima, Shin'ya Ohmori, Kinuko Ohneda

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh) mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the KitW-sh/W-sh stromal vascular fraction, suggesting the accumulation of preadipocytes. Moreover, the increased expression of preadipocyte genes was restored by mast cell reconstitution in the KitW-sh/W-sh mice. These results suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalFEBS Open Bio
Volume4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Adipogenesis
  • Mast cell
  • Obesity
  • White adipose tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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