Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

Noboru Motoyama, Fanping Wang, Kevin A. Roth, Hirofumi Sawa, Kei Ichi Nakayama, Keiko Nakayama, Izumi Negishi, Satoru Senju, Qing Zhang, Satoshi Fujii, Dennis Y. Loh

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Abstract

Bcl-x is a member of the bcl-2 gene family, which may regulate programmed cell death. Mice were generated that lacked Bcl-x. The Bcl-x-deficient mice died around embryonic day 13. Extensive apoptotic cell death was evident in postmitotic immature neurons of the developing brain, spinal cord, and dorsal root ganglia. Hematopoietic cells in the liver were also apoptotic. Analyses of bcl-x double-knockout chimeric mice showed that the maturation of Bcl-x-deficient lymphocytes was diminished. The life-span of immature lymphocytes, but not mature lymphocytes, was shortened. Thus, Bcl-x functions to support the viability of immature cells during the development of the nervous and hematopoietic systems.

Original languageEnglish
Pages (from-to)1506-1510
Number of pages5
JournalScience
Volume267
Issue number5203
DOIs
Publication statusPublished - 1995 Jan 1
Externally publishedYes

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    Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K. I., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., & Loh, D. Y. (1995). Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science, 267(5203), 1506-1510. https://doi.org/10.1126/science.7878471