Mass spectrometry for chemical diagnosis and pharmaceutical care

Nariyasu Mano, Miki Simada, Junichi Goto

Research output: Contribution to journalArticlepeer-review


Recently, mass spectrometry is expected to be big contributors in clinical practice. Especially, proteomics and metabolomics for searching disease biomarkers and new drug target molecules are now attracting attention, and the researches on the subjects including method developments are doing actively. Meanwhile, mass spectrometry coupled with chromatography has been already used for chemical diagnosis and therapeutic drug monitoring in pharmaceutical care, and its coverage is rapidly expanding combined with recent progress of method and biotechnology. In this article, we focused chemical diagnosis and pharmaceutical care mainly, and consider a future direction of clinical application of mass spectrometry with organizing its present problem.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalJapanese Journal of Clinical Chemistry
Issue number1
Publication statusPublished - 2010 Jan 1


  • Electrospray ionization
  • Liquid chromatography/tandem mass spectrometry
  • Matrix-assisted laser desorption/ionization
  • Newborn mass screening
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Clinical Biochemistry


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