Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16

Hiroaki Tomita, Koki Yamada, Mohsen Ghadami, Takako Ogura, Yoko Yanai, Katsumi Nakatomi, Miyuki Sadamatsu, Akira Masui, Nobumasa Kato, Norio Niikawa

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16 Citations (Scopus)

Abstract

Human earwax is a one-gene trait comprising two phenotypically distinct forms - wet and dry. This trait is attributed to secretory products of the ceruminous apocrine glands, and frequencies of phenotypes vary between ethnic groups. We did linkage analysis of eight Japanese families segregating earwax dimorphism. We assigned the earwax locus within a ∼7.42-cM region between the loci D16S3093 and D16S3080 on chromosome 16p11.2-16q12.1, with a maximum two-point LOD score of 11.15 (θ=0.00) at the locus D16S3044. Identification of the earwax locus could contribute to further anthropogenetic studies and physiological and pathological understanding of the apocrine-gland development.

Original languageEnglish
Pages (from-to)2000-2002
Number of pages3
JournalLancet
Volume359
Issue number9322
DOIs
Publication statusPublished - 2002 Jun 8
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Tomita, H., Yamada, K., Ghadami, M., Ogura, T., Yanai, Y., Nakatomi, K., Sadamatsu, M., Masui, A., Kato, N., & Niikawa, N. (2002). Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16. Lancet, 359(9322), 2000-2002. https://doi.org/10.1016/S0140-6736(02)08835-9