Kuwano, A, Ikeda, H., Takeda, K., Nakai, H., Kondo, I. and Shibahara, S. Mapping of the Human Gene for Inducible Heme Oxygenase to Chromosome 22ql2. Tohoku J. Exp. Med., 1994, 172 (4), 389-392 Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22ql2.-heme oxygenase; chromosome mapping; somatic cell hybrids; fluorescence in situ hybridization.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)