Mapping of the Human Gene for Inducible Heme Oxygenase to Chromosome 22ql2

Akira Kuwano, Ikuko Kondo, Hiroyuki Ikeda, Hiroshi Nakai, Kazuhisa Takeda, Shigeki Shibahara

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Kuwano, A, Ikeda, H., Takeda, K., Nakai, H., Kondo, I. and Shibahara, S. Mapping of the Human Gene for Inducible Heme Oxygenase to Chromosome 22ql2. Tohoku J. Exp. Med., 1994, 172 (4), 389-392 Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22ql2.-heme oxygenase; chromosome mapping; somatic cell hybrids; fluorescence in situ hybridization.

Original languageEnglish
Pages (from-to)389-392
Number of pages4
Journalthe tohoku journal of experimental medicine
Volume172
Issue number4
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Mapping of the Human Gene for Inducible Heme Oxygenase to Chromosome 22ql2'. Together they form a unique fingerprint.

Cite this