Mapping circulating serum miRNAs to their immune-related target mRNAs

Bakhtiyor Nosirov, Joël Billaud, Alexis Vandenbon, Diego Diez, Edward Wijaya, Ken J. Ishii, Shunsuke Teraguchi, Daron M. Standley

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Evidence suggests that circulating serum microRNAs (miRNAs) might preferentially target immune-related mRNAs. If this were the case, we hypothesized that immune-related mRNAs would have more predicted serum miRNA binding sites than other mRNAs and, reciprocally, that serum miRNAs would have more immune-related mRNA targets than nonserum miRNAs. Materials and methods: We developed a consensus target predictor using the random forest framework and calculated the number of predicted miRNA-mRNA interactions in various subsets of miRNAs (serum, non-serum) and mRNAs (immune related, nonimmune related). Results: Immune-related mRNAs were predicted to be targeted by serum miRNA more than other mRNAs. Moreover, serum miRNAs were predicted to target many more immune-related mRNA targets than non-serum miRNAs; however, these two biases in immune-related mRNAs and serum miRNAs appear to be completely independent. Conclusion: Immune-related mRNAs have more miRNA binding sites in general, not just for serum miRNAs; likewise, serum miRNAs target many more mRNAs than non-serum miRNAs overall, regardless of whether they are immune related or not. Nevertheless, these two independent phenomena result in a significantly larger number of predicted serum miRNA-immune mRNA interactions than would be expected by chance.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAdvances and Applications in Bioinformatics and Chemistry
Volume10
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Biomarker
  • Posttranscriptional regulation
  • Random forest
  • Target prediction

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Computer Science Applications

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  • Cite this

    Nosirov, B., Billaud, J., Vandenbon, A., Diez, D., Wijaya, E., Ishii, K. J., Teraguchi, S., & Standley, D. M. (2017). Mapping circulating serum miRNAs to their immune-related target mRNAs. Advances and Applications in Bioinformatics and Chemistry, 10(1), 1-9. https://doi.org/10.2147/AABC.S121598