Management of nevi originated from the epidermis and its appendages

Yasuo Sakai, Ken Matsuda, Yoshitaka Fukuzumi, Ko Hosokawa

    Research output: Contribution to journalArticlepeer-review


    Among nevi originated from the epidermis and its appendages, epidermal nevus and sebaceous nevus are common for a plastic surgeon. Both of them appear as visible, circumscribed lesions at birth or in early infancy. Many therapeutic modalities have been employed for epidermal nevus including surgical excision, abrasion using laser and topical treatment with various chemicals, but no ideal treatment is available yet. As far as sebaceous nevus is concerned, surgical excision is recommended due to benign or malignant neoplastic changes. Although recent studies have indicated that the development of basal cell carcinoma or other malignant neoplasm is very rare, this remains a controversial issue. Recently a genetic mosaic caused by postzygotic somatic mutations has been shown to result in a nevus, which may be the clue to dissolving mechanisms of tumor formation in sebaceous nevus.

    Original languageEnglish
    Pages (from-to)755-763
    Number of pages9
    JournalJapanese Journal of Plastic Surgery
    Issue number7
    Publication statusPublished - 2010 Jul

    ASJC Scopus subject areas

    • Surgery


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