Malignant transformation of pleomorphic xanthoastrocytoma

T. Nakajima, T. Kumabe, H. Shamoto, M. Watanabe, H. Suzuki, T. Tominaga

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

A 31-year-old woman presented with a pleomorphic xantho-astrocytoma (PXA) manifesting as epilepsy. The tumour was partially resected. Histological examination revealed cellular pleomorphism and cytoplasmic vacuolation consistent with PXA, but no mitoses, necrosis, or endothelial proliferation. Follow-up neuro-imaging showed the residual tumour had grown rapidly with dissemination in the spinal cord. The recurrent lesion was totally resected and was shown to be glioblastoma. The patient has survived without signs of recurrence for 36 months after adjuvant radiochemotherapy. The biological behaviour of PXA cannot be predicted based on the histological features and careful follow up is essential.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalActa neurochirurgica
Volume148
Issue number1
DOIs
Publication statusPublished - 2006 Jan

Keywords

  • Glioblastoma
  • Malignant transformation
  • Pleomorphic xanthoastrocytoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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