TY - JOUR
T1 - Malignant transformation of pleomorphic xanthoastrocytoma
AU - Nakajima, T.
AU - Kumabe, T.
AU - Shamoto, H.
AU - Watanabe, M.
AU - Suzuki, H.
AU - Tominaga, T.
PY - 2006/1
Y1 - 2006/1
N2 - A 31-year-old woman presented with a pleomorphic xantho-astrocytoma (PXA) manifesting as epilepsy. The tumour was partially resected. Histological examination revealed cellular pleomorphism and cytoplasmic vacuolation consistent with PXA, but no mitoses, necrosis, or endothelial proliferation. Follow-up neuro-imaging showed the residual tumour had grown rapidly with dissemination in the spinal cord. The recurrent lesion was totally resected and was shown to be glioblastoma. The patient has survived without signs of recurrence for 36 months after adjuvant radiochemotherapy. The biological behaviour of PXA cannot be predicted based on the histological features and careful follow up is essential.
AB - A 31-year-old woman presented with a pleomorphic xantho-astrocytoma (PXA) manifesting as epilepsy. The tumour was partially resected. Histological examination revealed cellular pleomorphism and cytoplasmic vacuolation consistent with PXA, but no mitoses, necrosis, or endothelial proliferation. Follow-up neuro-imaging showed the residual tumour had grown rapidly with dissemination in the spinal cord. The recurrent lesion was totally resected and was shown to be glioblastoma. The patient has survived without signs of recurrence for 36 months after adjuvant radiochemotherapy. The biological behaviour of PXA cannot be predicted based on the histological features and careful follow up is essential.
KW - Glioblastoma
KW - Malignant transformation
KW - Pleomorphic xanthoastrocytoma
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U2 - 10.1007/s00701-005-0549-8
DO - 10.1007/s00701-005-0549-8
M3 - Article
C2 - 15912255
AN - SCOPUS:29244483383
VL - 148
SP - 67
EP - 71
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
SN - 0001-6268
IS - 1
ER -