Malignant transformation of pleomorphic xanthoastrocytoma

T. Nakajima; T. Kumabe; H. Shamoto; M. Watanabe; H. Suzuki; T. Tominaga

doi:10.1007/s00701-005-0549-8

Malignant transformation of pleomorphic xanthoastrocytoma

T. Nakajima, T. Kumabe, H. Shamoto, M. Watanabe, H. Suzuki, T. Tominaga

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

A 31-year-old woman presented with a pleomorphic xantho-astrocytoma (PXA) manifesting as epilepsy. The tumour was partially resected. Histological examination revealed cellular pleomorphism and cytoplasmic vacuolation consistent with PXA, but no mitoses, necrosis, or endothelial proliferation. Follow-up neuro-imaging showed the residual tumour had grown rapidly with dissemination in the spinal cord. The recurrent lesion was totally resected and was shown to be glioblastoma. The patient has survived without signs of recurrence for 36 months after adjuvant radiochemotherapy. The biological behaviour of PXA cannot be predicted based on the histological features and careful follow up is essential.

Original language	English
Pages (from-to)	67-71
Number of pages	5
Journal	Acta neurochirurgica
Volume	148
Issue number	1
DOIs	https://doi.org/10.1007/s00701-005-0549-8
Publication status	Published - 2006 Jan

Keywords

Glioblastoma
Malignant transformation
Pleomorphic xanthoastrocytoma

ASJC Scopus subject areas

Surgery
Clinical Neurology

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AU - Kumabe, T.

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AU - Watanabe, M.

AU - Suzuki, H.

AU - Tominaga, T.

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