Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy

Shunsuke Kikuchi; Daisuke Kanoh; Shinichi Sato; Yoshinori Sakurai; Minoru Suzuki; Hiroyuki Nakamura

doi:10.1016/j.jconrel.2016.07.017

Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC): Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy

Shunsuke Kikuchi, Daisuke Kanoh, Shinichi Sato, Yoshinori Sakurai, Minoru Suzuki, Hiroyuki Nakamura

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.

Original language	English
Pages (from-to)	160-167
Number of pages	8
Journal	Journal of Controlled Release
Volume	237
DOIs	https://doi.org/10.1016/j.jconrel.2016.07.017
Publication status	Published - 2016 Sep 10
Externally published	Yes

Keywords

Albumin modification
Boron delivery system
Boron neutron capture therapy (BNCT)
Closo-dodecaborate
Maleimide

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2016.07.017

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Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC) : Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy. / Kikuchi, Shunsuke; Kanoh, Daisuke; Sato, Shinichi; Sakurai, Yoshinori; Suzuki, Minoru; Nakamura, Hiroyuki.

In: Journal of Controlled Release, Vol. 237, 10.09.2016, p. 160-167.

Research output: Contribution to journal › Article › peer-review

Kikuchi, Shunsuke ; Kanoh, Daisuke ; Sato, Shinichi ; Sakurai, Yoshinori ; Suzuki, Minoru ; Nakamura, Hiroyuki. / Maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC) : Unique ligation at cysteine and lysine residues enables efficient boron delivery to tumor for neutron capture therapy. In: Journal of Controlled Release. 2016 ; Vol. 237. pp. 160-167.

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abstract = "Maleimide-conjugating closo-dodecaborate sodium form 5c (MID) synthesized by the nucleophilic ring-opening reaction of closo-dodecaborate-1,4-dioxane complex 2 with tetrabutylammonium (TBA) azide was found to conjugate to free SH of cysteine and lysine residues in BSA under physiological conditions, forming highly boronated BSA that showed high and selective accumulation in tumor and significant tumor growth inhibition in colon 26 tumor-bearing mice subjected to thermal neutron irradiation.",

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AU - Suzuki, Minoru

AU - Nakamura, Hiroyuki

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