TY - JOUR
T1 - Maladaptive change of body representation in the brain after damage to central or peripheral nervous system
AU - Oouchida, Yutaka
AU - Sudo, Tamami
AU - Inamura, Tetsunari
AU - Tanaka, Naofumi
AU - Ohki, Yukari
AU - Izumi, Shin ichi
N1 - Funding Information:
This work was partially supported by JSPS KAKENHI, Grant-in-Aid for Scientific Research on Innovative Areas “Neurorehabilitation based upon brain plasticity on body representations” (Grant Number 26120007 ).
Publisher Copyright:
© 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Our brain has great flexibility to cope with various changes in the environment. Use-dependent plasticity, a kind of functional plasticity, plays the most important role in this ability to cope. For example, the functional recovery of paretic limb motor movement during post-stroke rehabilitation depends mainly on how much it is used. Patients with hemiparesis, however, tend to gradually disuse the paretic limb because of its motor impairment. Decreased use of the paretic hand then leads to further functional decline brought by use-dependent plasticity. To break this negative loop, body representation, which is the conscious and unconscious information regarding body state stored in the brain, is key for using the paretic limb because it plays an important role in selecting an effector while a motor program is generated. In an attempt to understand body representation in the brain, we reviewed animal and human literature mainly on the alterations of the sensory maps in the primary somatosensory cortex corresponding to the changes in limb usage caused by peripheral or central nervous system damage.
AB - Our brain has great flexibility to cope with various changes in the environment. Use-dependent plasticity, a kind of functional plasticity, plays the most important role in this ability to cope. For example, the functional recovery of paretic limb motor movement during post-stroke rehabilitation depends mainly on how much it is used. Patients with hemiparesis, however, tend to gradually disuse the paretic limb because of its motor impairment. Decreased use of the paretic hand then leads to further functional decline brought by use-dependent plasticity. To break this negative loop, body representation, which is the conscious and unconscious information regarding body state stored in the brain, is key for using the paretic limb because it plays an important role in selecting an effector while a motor program is generated. In an attempt to understand body representation in the brain, we reviewed animal and human literature mainly on the alterations of the sensory maps in the primary somatosensory cortex corresponding to the changes in limb usage caused by peripheral or central nervous system damage.
KW - Body representation
KW - Phantom limb
KW - Rehabilitation
KW - Sensory map
KW - Use-dependent plasticity
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U2 - 10.1016/j.neures.2015.12.015
DO - 10.1016/j.neures.2015.12.015
M3 - Review article
C2 - 26748075
AN - SCOPUS:84962081622
VL - 104
SP - 38
EP - 43
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
ER -