Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1

Chihiro Mori; Takako Takanami; Atsushi Higashitani

doi:10.1534/genetics.108.090704

Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1

Chihiro Mori, Takako Takanami, Atsushi Higashitani

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.

Original language	English
Pages (from-to)	681-686
Number of pages	6
Journal	Genetics
Volume	180
Issue number	1
DOIs	https://doi.org/10.1534/genetics.108.090704
Publication status	Published - 2008 Sep

ASJC Scopus subject areas

Genetics

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abstract = "Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.",

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