TY - JOUR
T1 - Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1
AU - Mori, Chihiro
AU - Takanami, Takako
AU - Higashitani, Atsushi
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.
AB - Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.
UR - http://www.scopus.com/inward/record.url?scp=56049115130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56049115130&partnerID=8YFLogxK
U2 - 10.1534/genetics.108.090704
DO - 10.1534/genetics.108.090704
M3 - Article
C2 - 18716329
AN - SCOPUS:56049115130
VL - 180
SP - 681
EP - 686
JO - Genetics
JF - Genetics
SN - 0016-6731
IS - 1
ER -