Maintenance of high virus load even after seroconversion in newborn cats acutely infected with feline immunodeficiency virus

Kenzo Tokunaga, Koichi Shoda, Yoshii Nishino, Shiro Mori, Qiu Zhong, Yong Hui Zheng, Masahiko Kishi, Chiaki Ishihara, Masanori Kanda, Kazuyoshi Ikuta

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The viral loads in adult and newborn cats have been compared following injection with feline CD4+ FeL-039 line cells acutely infected with feline immunodeficiency virus (FIV). The level of virus genome in peripheral blood mononuclear cells (PBMC) increased progressively despite seroconversion in the newborn cats, whereas the virus genome was apparently cleared after seroconversion in the adult cats. Immunohistochemical staining of thymus of the FIV-infected newborn cats showed clusters of viral antigen-positive cells. These results indicate that FIV infection of the newborn cat results in higher virus loads than infection of the adult cat. We discuss these findings in relation to FIV as a model system for studies of the infection of neonates with an immunosuppressive retrovirus.

Original languageEnglish
Pages (from-to)1393-1398
Number of pages6
JournalVaccine
Volume13
Issue number15
DOIs
Publication statusPublished - 1995

Keywords

  • FIV
  • newborn cat
  • tolerance
  • virus load

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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