TY - JOUR
T1 - Magnitude of transmural heterogeneity as a dominant factor for LVEDP elevation in HCM
AU - Koiwa, Yoshiro
AU - Kamada, Hide Ichi
AU - Ikeda, Jun
AU - Inose, Mikio
AU - Shirado, Kunio
AU - Saito, Yoshiko
AU - Honda, Hideyuki
AU - Kanai, Hiroshi
AU - Hasegawa, Hideyuki
PY - 2001
Y1 - 2001
N2 - Using the phased tracking method (Doppler frequency: 3 MHz, PRF: 9 kHz), we examined transmural physical heterogeneity could be a determinant factor of the left ventricular end-diastolic pressure (LVEDP) elevation in HCM. In normal and AS patients, no heterogeneity in the transmural response of the vertical velocity at each preset point (0.75mm-intervals in depth) and the change in each transmural layer thickness across the septum to the mitral inflow was observed. In HCM, the magnitude and the timing of the velocity at each preset point showed remarkable variation among myocardial layers across the septum. The "passive thickening" by atrial inflow was observed at several layers by these temporal and amplitude heterogeneities of transmural velocity distribution. The % of layers showing "passive thickness" during the atrial contraction period was strongly correlated to LVEDP. We concluded that the transmural heterogeneity plays an important role in the LVEDP elevation in HCM patients.
AB - Using the phased tracking method (Doppler frequency: 3 MHz, PRF: 9 kHz), we examined transmural physical heterogeneity could be a determinant factor of the left ventricular end-diastolic pressure (LVEDP) elevation in HCM. In normal and AS patients, no heterogeneity in the transmural response of the vertical velocity at each preset point (0.75mm-intervals in depth) and the change in each transmural layer thickness across the septum to the mitral inflow was observed. In HCM, the magnitude and the timing of the velocity at each preset point showed remarkable variation among myocardial layers across the septum. The "passive thickening" by atrial inflow was observed at several layers by these temporal and amplitude heterogeneities of transmural velocity distribution. The % of layers showing "passive thickness" during the atrial contraction period was strongly correlated to LVEDP. We concluded that the transmural heterogeneity plays an important role in the LVEDP elevation in HCM patients.
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M3 - Conference article
AN - SCOPUS:0035731213
VL - 2
SP - 1245
EP - 1248
JO - Proceedings - IEEE Ultrasonics Symposium
JF - Proceedings - IEEE Ultrasonics Symposium
SN - 1051-0117
T2 - 2001 Ultrasonics Symposium
Y2 - 6 October 2001 through 10 October 2001
ER -