TY - JOUR
T1 - Magnetoencephalography's higher sensitivity to epileptic spikes may elucidate the profile of electroencephalographically negative epileptic seizures
AU - Kakisaka, Yosuke
AU - Wang, Zhong I.
AU - Mosher, John C.
AU - Nair, Dileep R.
AU - Alexopoulos, Andreas V.
AU - Burgess, Richard C.
N1 - Funding Information:
This work was supported in part by grants from the National Institute of Biomedical Imaging and BioEngineering ( R01-EB009048 and R01-EB002010 ) and the National Institute of General Medical Sciences ( DP2 OD006469-01 ).
PY - 2012/2
Y1 - 2012/2
N2 - Video electroencephalography (EEG) plays an important role in judging whether a clinical spell is an epileptic seizure or paroxysmal event, but its interpretation is not always straightforward. If clinical events without EEG correlates are strongly suggestive of seizures, we usually regard these spells as epileptic seizures. However, the electric/magnetic physiological profile of EEG-negative epileptic seizures remains unknown. We describe a 19-year-old man known to have epileptic seizures, in which both magnetoencephalography (MEG)-unique and EEG/MEG spikes were seen. Both types of spikes originated from the same source, but the EEG/MEG spikes were of significantly higher magnitude than the MEG-unique spikes. Therefore, some epileptic seizures, even though generated identically to the MEG-positive seizures, could be EEG-negative because of their smaller magnitude.
AB - Video electroencephalography (EEG) plays an important role in judging whether a clinical spell is an epileptic seizure or paroxysmal event, but its interpretation is not always straightforward. If clinical events without EEG correlates are strongly suggestive of seizures, we usually regard these spells as epileptic seizures. However, the electric/magnetic physiological profile of EEG-negative epileptic seizures remains unknown. We describe a 19-year-old man known to have epileptic seizures, in which both magnetoencephalography (MEG)-unique and EEG/MEG spikes were seen. Both types of spikes originated from the same source, but the EEG/MEG spikes were of significantly higher magnitude than the MEG-unique spikes. Therefore, some epileptic seizures, even though generated identically to the MEG-positive seizures, could be EEG-negative because of their smaller magnitude.
KW - Electroencephalography-negative seizures
KW - Electroencephalograpic/magnetoencephalographic spikes
KW - Magnetoencephalography
KW - Magnetoencephalography-unique
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U2 - 10.1016/j.yebeh.2011.09.019
DO - 10.1016/j.yebeh.2011.09.019
M3 - Article
C2 - 22227034
AN - SCOPUS:84856789113
VL - 23
SP - 171
EP - 173
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
SN - 1525-5050
IS - 2
ER -