Magnetoencephalography localizing spike sources of atypical benign partial epilepsy

Hideaki Shiraishi, Kazuhiro Haginoya, Eiji Nakagawa, Shinji Saitoh, Yutaka Kaneko, Nobukazu Nakasato, Derrick Chan, Hiroshi Otsubo

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Rationale: Atypical benign partial epilepsy (ABPE) is characterized by centro-temporal electroencephalography (EEG) spikes, continuous spike and waves during sleep (CSWS), and multiple seizure types including epileptic negative myoclonus (ENM), but not tonic seizures. This study evaluated the localization of magnetoencephalography (MEG) spike sources (MEGSSs) to investigate the clinical features and mechanism underlying ABPE. Methods: We retrospectively analyzed seizure profiles, scalp video EEG (VEEG) and MEG in ABPE patients. Results: Eighteen ABPE patients were identified (nine girls and nine boys). Seizure onset ranged from 1.3 to 8.8. years (median, 2.9. years). Initial seizures consisted of focal motor seizures (15 patients) and absences/atypical absences (3). Seventeen patients had multiple seizure types including drop attacks (16), focal motor seizures (16), ENM (14), absences/atypical absences (11) and focal myoclonic seizures (10). VEEG showed centro-temporal spikes and CSWS in all patients. Magnetic resonance imaging (MRI) was reported as normal in all patients. MEGSSs were localized over the following regions: both Rolandic and sylvian (8), peri-sylvian (5), peri-Rolandic (4), parieto-occipital (1), bilateral (10) and unilateral (8). All patients were on more than two antiepileptic medications. ENM and absences/atypical absences were controlled in 14 patients treated with adjunctive ethosuximide. Conclusion: MEG localized the source of centro-temporal spikes and CSWS in the Rolandic-sylvian regions. Centro-temporal spikes, Rolandic-sylvian spike sources and focal motor seizures are evidence that ABPE presents with Rolandic-sylvian onset seizures. ABPE is therefore a unique, age-related and localization-related epilepsy with a Rolandic-sylvian epileptic focus plus possible thalamo-cortical epileptic networks in the developing brain of children.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalBrain and Development
Volume36
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • Atypical absence
  • Centro-temporal spike
  • Continuous spike and waves during sleep
  • Epileptic negative myoclonus
  • Focal seizure
  • Secondary bilateral synchrony

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Magnetoencephalography localizing spike sources of atypical benign partial epilepsy'. Together they form a unique fingerprint.

Cite this