Magnetite nanoparticles with high heating efficiencies for application in the hyperthermia of cancer

Zhixia Li, Masakazu Kawashita, Norio Araki, Michihide Mitsumori, Masahiro Hiraoka, Masaaki Doi

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Magnetic hyperthermia is a safe method for cancer therapy. A gap-type alternating current magnetic field (100 kHz, 100-300 Oe) is expected to be clinically applicable for magnetic hyperthermia. In this study, magnetite nanoparticles (MNPs) varying in size from 8 to 413 nm were synthesized using a chemical coprecipitation and an oxidation precipitation method to find the optimum particle size that shows a high heating efficiency in an applied magnetic field. The particles' in vitro heating efficiency in an agar phantom at an MNP concentration of 58 mg Fe/ml was measured in an applied magnetic field. In a magnetic field of 120 Oe, the temperature increase (ΔT) of the agar phantom within 30 s was 9.3 °C for MNPs with a size of 8 nm, but was less for the other samples, while in a magnetic field of 300 Oe, ΔT = 55 °C for MNPs with a size of 24 nm, and ΔT = 25 °C for MNPs with a size of 8 nm. The excellent heating efficiency of MNPs with a size of 24 nm in a magnetic field of 300 Oe may be due to a combination of the effects of both relaxation and hysteresis losses of the magnetic particles. It is believed that MNPs with a size of 8-24 nm will be useful for the in situ hyperthermia treatment of cancer.

Original languageEnglish
Pages (from-to)990-996
Number of pages7
JournalMaterials Science and Engineering C
Volume30
Issue number7
DOIs
Publication statusPublished - 2010 Aug 30

Keywords

  • Heat efficiency
  • Hyperthermia
  • Hysteresis loss
  • Magnetite nanoparticle
  • Particle size

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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