Magnetic resonance imaging of breast cancer: correlation between contrast enhancement and tumor angiogenesis

A. Furuta, T. Ishibashi, Syouki Takahashi, S. Yamada, N. Ohuchi, G. Amano, K. Goto, M. Watanabe

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


PURPOSE: To evaluate the association between enhancement characteristics of breast cancers obtained by three-dimensional dynamic MRI and histopathologic findings, especially tumor angiogenesis. MATERIALS AND METHODS: Forty-four women with invasive breast cancer under went preoperative MR imaging. Three-dimensional fast low angle shot (3D-FLASH) images of the whole breast (section thickness, 2 mm; gap, 0 mm; number of sections, 50; acquisition time, 87 sec) were obtained at 90-second intervals for three images (the first image before the injection of Gd-DTPA). Microvessel densities were evaluated in specimens immunohistochemically stained with anti-CD34 antibody. Pearson correlation tests were used to determine the strength of the relationships between enhancement parameters and microvessel densities. Univariate and multivariate analyses were performed to explore the associations with histopathologic factors, including histological grade. RESULTS: The enhancement parameters were correlated with microvessel densities (p < 0.0001). The peripheral microvessel densities were significantly higher than central microvessel densities (p < 0.0001). A significant association with histological grade was observed for the steepest slopes of the dynamic curve and microvessel densities (p < 0.05). CONCLUSION: A correlation between three-dimensional dynamic MRI parameters and microvessel densities, and associations with histological grade were seen. This may allow MRI to be used in the prediction of tumor angiogenesis and tumor grade.

Original languageEnglish
Pages (from-to)682-688
Number of pages7
JournalNihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica
Issue number12
Publication statusPublished - 1999 Oct

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology


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