Magnetic Nanoparticle Detection by Utilizing Nonlinear Magnetization for Sentinel Lymph Nodes of Breast Cancer Patients

Akihiro Kuwahata, Kanae Taruno, Tomoko Kurita, Masujiro Makita, Shinichi Chikaki, Itsuro Saito, Hiroyuki Takei, Seigo Nakamura, Moriaki Kusakabe, Masaki Sekino

Research output: Contribution to journalArticlepeer-review

Abstract

To minimize the invasiveness and improve the patient's quality of life, sentinel lymph node (SLN) biopsy with magnetic nanoparticles (MNPs) containing superparamagnetic iron oxide is performed on breast cancer patients. Identifying the first SLN by quantification of the amount of MNPs can help to investigate the cancer metastasis. We developed the device for performing iron quantification during surgery. The compact desktop-size device can be easily introduced into operation rooms, and simple system of the device enables identification of the first SLN. We investigated the optimum nonlinear magnetic responses that are attributed to magnetic relaxations under moderate small ac and dc magnetic fields (1 mT) and found that ac magnetic fields with < 5 kHz are effective in the detection of MNPs. In addition, our clinical trials revealed more iron ( 40μg ) in the first lymph node than in the second lymph node ( 10μg ), clearly indicating intraoperative quantification in the first node.

Original languageEnglish
Article number9145714
JournalIEEE Transactions on Magnetics
Volume57
Issue number2
DOIs
Publication statusPublished - 2021 Feb
Externally publishedYes

Keywords

  • Iron quantification device
  • magnetic nanoparticles (MNPs)
  • nonlinear magnetization
  • sentinel lymph node biopsy (SLNB)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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