Abstract
We present proof-of-principle experiments and simulations that demonstrate a new technology in which biological assay microscopic tags carrying multi-bit magnetic codes are used to label probe biomolecules. It is demonstrated that these 'micro-barcode tags' can be encoded, transported using micro-fluidics and are compatible with surface chemistry. We also present simulations and experimental results which suggest the feasibility of decoding the micro-barcode tags using magnetoresistive sensors. Together, these results demonstrate substantial progress towards meeting the critical requirements of a magnetically encoded, high-throughput and portable biological assay platform. We also show that an extension of our technology could potentially be used to label libraries consisting of ∼104 distinct probe molecules, and could therefore have a strong impact on mainstream medical diagnostics.
Original language | English |
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Article number | 175001 |
Journal | Journal of Physics D: Applied Physics |
Volume | 43 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Acoustics and Ultrasonics
- Surfaces, Coatings and Films