Magnetic micro-barcodes for molecular tagging applications

T. J. Hayward, B. Hong, K. N. Vyas, J. J. Palfreyman, J. F.K. Cooper, Z. Jiang, J. R. Jeong, J. Llandro, T. Mitrelias, J. A.C. Bland, C. H.W. Barnes

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

We present proof-of-principle experiments and simulations that demonstrate a new technology in which biological assay microscopic tags carrying multi-bit magnetic codes are used to label probe biomolecules. It is demonstrated that these 'micro-barcode tags' can be encoded, transported using micro-fluidics and are compatible with surface chemistry. We also present simulations and experimental results which suggest the feasibility of decoding the micro-barcode tags using magnetoresistive sensors. Together, these results demonstrate substantial progress towards meeting the critical requirements of a magnetically encoded, high-throughput and portable biological assay platform. We also show that an extension of our technology could potentially be used to label libraries consisting of ∼104 distinct probe molecules, and could therefore have a strong impact on mainstream medical diagnostics.

Original languageEnglish
Article number175001
JournalJournal of Physics D: Applied Physics
Volume43
Issue number17
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Acoustics and Ultrasonics
  • Surfaces, Coatings and Films

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