Magnesium increases calcium absorption mediated by transcellular transport in small intestine of goats and rats

T. Kozakai; K. Katoh; Y. Obara

doi:10.22358/jafs/73886/2004

Magnesium increases calcium absorption mediated by transcellular transport in small intestine of goats and rats

T. Kozakai, K. Katoh, Y. Obara

Research output: Contribution to journal › Article › peer-review

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Abstract

The effect of an increase in mucosal Mg concentration on Ca absorption mediated by transcellular transport in the stripped epithelia of caprine ileum and rat jejunum was studied. In Ussing chamber experiments, mucosal to serosal flux of Ca (Jms) at 60 mM MgCl₂ was significantly (P<0.05) greater than that of control (1.2 mM) in the absence of electrochemical gradient in goats and rats. Furthermore, Mg-induced Jms was significantly decreased (P<0.05) after pre-incubation with thapsigargin. It is concluded that Mg stimulates Ca absorption mediated by transcellular transport, which contributed to the Ca store of endoplasmic reticulum.

Original language	English
Pages (from-to)	277-280
Number of pages	4
Journal	Journal of Animal and Feed Sciences
Volume	13
Issue number	SUPPL. 1
DOIs	https://doi.org/10.22358/jafs/73886/2004
Publication status	Published - 2004

Keywords

Calcium absorption
Intestinal epithelia
Magnesium
Transcellular pathway

ASJC Scopus subject areas

Food Science
Animal Science and Zoology

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10.22358/jafs/73886/2004

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T1 - Magnesium increases calcium absorption mediated by transcellular transport in small intestine of goats and rats

AU - Kozakai, T.

AU - Katoh, K.

AU - Obara, Y.

PY - 2004

Y1 - 2004

N2 - The effect of an increase in mucosal Mg concentration on Ca absorption mediated by transcellular transport in the stripped epithelia of caprine ileum and rat jejunum was studied. In Ussing chamber experiments, mucosal to serosal flux of Ca (Jms) at 60 mM MgCl2 was significantly (P<0.05) greater than that of control (1.2 mM) in the absence of electrochemical gradient in goats and rats. Furthermore, Mg-induced Jms was significantly decreased (P<0.05) after pre-incubation with thapsigargin. It is concluded that Mg stimulates Ca absorption mediated by transcellular transport, which contributed to the Ca store of endoplasmic reticulum.

AB - The effect of an increase in mucosal Mg concentration on Ca absorption mediated by transcellular transport in the stripped epithelia of caprine ileum and rat jejunum was studied. In Ussing chamber experiments, mucosal to serosal flux of Ca (Jms) at 60 mM MgCl2 was significantly (P<0.05) greater than that of control (1.2 mM) in the absence of electrochemical gradient in goats and rats. Furthermore, Mg-induced Jms was significantly decreased (P<0.05) after pre-incubation with thapsigargin. It is concluded that Mg stimulates Ca absorption mediated by transcellular transport, which contributed to the Ca store of endoplasmic reticulum.

KW - Calcium absorption

KW - Intestinal epithelia

KW - Magnesium

KW - Transcellular pathway

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Magnesium increases calcium absorption mediated by transcellular transport in small intestine of goats and rats

Abstract

Keywords

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