MAFFT online service: Multiple sequence alignment, interactive sequence choice and visualization

Kazutaka Katoh, John Rozewicki, Kazunori D. Yamada

Research output: Contribution to journalArticlepeer-review

2780 Citations (Scopus)


This article describes several features in the MAFFT online service for multiple sequence alignment (MSA). As a result of recent advances in sequencing technologies, huge numbers of biological sequences are available and the need for MSAs with large numbers of sequences is increasing. To extract biologically relevant information from such data, sophistication of algorithms is necessary but not sufficient. Intuitive and interactive tools for experimental biologists to semiautomatically handle large data are becoming important. We are working on development of MAFFT toward these two directions. Here, we explain (i) the Web interface for recently developed options for large data and (ii) interactive usage to refine sequence data sets and MSAs.

Original languageEnglish
Pages (from-to)1160-1166
Number of pages7
JournalBriefings in Bioinformatics
Issue number4
Publication statusPublished - 2018 Mar 27


  • multiple sequence alignment
  • phylogenetic tree
  • sequence analysis

ASJC Scopus subject areas

  • Information Systems
  • Molecular Biology


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