Emoglobinuria macroscopica secondaria a infezione da Mycoplasma pneumoniae trattata con successo con claritromicina

Translated title of the contribution: Macroscopic haemoglobinuria associated with mycoplasma pneumoniae infection successfully treated by clarithromycin

Itsuro Kazama, Tsutomu Tamada, Toshiyuki Nakajima

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A 25-year-old man developed macroscopic haemoglobinuria after a persistent dry cough. Although chest radiograph findings were normal, since the serum antibody for Mycoplasma pneumoniae was significantly elevated, a diagnosis infection with this organism was made. Despite the absence of apparent anaemia, a marked increase in serum haemolytic markers and positive result for urine haemoglobin indicated the haemolysis of red blood cells, which was likely to have occurred secondarily to M. pneumoniae infection. Shortly after the initiation of a macrolide antibiotic, clarithromycin, the patient’s haemoglobinuria completely disappeared together with a complete resolution of his respiratory symptoms. In this case, due to the lymphocyte-stimulatory nature of M. pneumoniae, an enhanced immune response, such as the production of cold agglutinins, was likely to be involved in the pathogenesis of erythrocyte haemolysis. The immunomodulatory property of clarithromycin was thought to repress the increased immunological reaction and thus enable the resolution of the urine abnormality.

Translated title of the contributionMacroscopic haemoglobinuria associated with mycoplasma pneumoniae infection successfully treated by clarithromycin
Original languageItalian
Pages (from-to)74-78
Number of pages5
JournalInfezioni in Medicina
Volume23
Issue number1
Publication statusPublished - 2015

Keywords

  • Clarithromycin
  • Erythrocyte haemolysis
  • Increased immunological reaction
  • Macroscopic haemoglobinuria
  • Mycoplasma pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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