TY - JOUR
T1 - Macrophage recognition of crystals and nanoparticles
AU - Nakayama, Masafumi
N1 - Funding Information:
This work was supported by Grants in Aid for Scientific Research (B) #16H02960 from the Japan Society for the Promotion of Science (JSPS) and by PRESTO #JPMJPR17H9 from the Japan Science and Technology Agency (JST).
Publisher Copyright:
© 2018 Nakayama.
PY - 2018/1/29
Y1 - 2018/1/29
N2 - Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles. Several recent studies have reported that some crystal particles are negatively charged and are recognized by scavenger receptor family members in a charge-dependent manner. Alternatively, a model for receptor-independent phagocytosis of crystals has also been proposed. This review focuses on the mechanisms by which macrophages recognize crystals and nanoparticles.
AB - Inhalation of exogenous crystals such as silica, asbestos, and carbon nanotubes can cause lung fibrosis and cancer. Endogenous crystals such as monosodium urate, cholesterol, and hydroxyapatite are associated with pathogenesis of gout, atherosclerosis, and osteoarthritis, respectively. These crystal-associated-inflammatory diseases are triggered by the macrophage NLRP3 inflammasome activation and cell death. Therefore, it is important to understand how macrophages recognize crystals. However, it is unlikely that macrophages have evolutionally acquired receptors specific for crystals or recently emerged nanoparticles. Several recent studies have reported that some crystal particles are negatively charged and are recognized by scavenger receptor family members in a charge-dependent manner. Alternatively, a model for receptor-independent phagocytosis of crystals has also been proposed. This review focuses on the mechanisms by which macrophages recognize crystals and nanoparticles.
KW - Crystals
KW - Inflammation
KW - Macrophages
KW - Nanoparticles
KW - Phagocytosis
KW - Scavenger receptors
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U2 - 10.3389/fimmu.2018.00103
DO - 10.3389/fimmu.2018.00103
M3 - Review article
AN - SCOPUS:85041105553
VL - 9
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
IS - JAN
M1 - 103
ER -