Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method

Jian Zhang, Sachiko Hiromoto, Tomohiko Yamazaki, Hua Huang, Gaozhi Jia, Haiyan Li, Guangyin Yuan

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments. Besides, an electrochemical method was proposed to prepare enough amount of degradation products in vitro efficiently.

Original languageEnglish
Pages (from-to)1178-1183
Number of pages6
JournalMaterials Science and Engineering C
Volume75
DOIs
Publication statusPublished - 2017 Jun 1
Externally publishedYes

Keywords

  • Degradation product
  • In vitro
  • Macrophage phagocytosis
  • Magnesium alloy

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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