Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy

Pierre Leclerc, Cedric Ray, Laurent Mahieu-Williame, Laure Alston, Carole Frindel, Pierre François Brevet, David Meyronet, Jacques Guyotat, Bruno Montcel, David Rousseau

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Gliomas are infiltrative brain tumors with a margin difficult to identify. 5-ALA induced PpIX fluorescence measurements are a clinical standard, but expert-based classification models still lack sensitivity and specificity. Here a fully automatic clustering method is proposed to discriminate glioma margin. This is obtained from spectroscopic fluorescent measurements acquired with a recently introduced intraoperative set up. We describe a data-driven selection of best spectral features and show how this improves results of margin prediction from healthy tissue by comparison with the standard biomarker-based prediction. This pilot study based on 10 patients and 50 samples shows promising results with a best performance of 77% of accuracy in healthy tissue prediction from margin tissue.

Original languageEnglish
Article number1462
JournalScientific reports
Volume10
Issue number1
DOIs
Publication statusPublished - 2020 Dec 1

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Machine learning-based prediction of glioma margin from 5-ALA induced PpIX fluorescence spectroscopy'. Together they form a unique fingerprint.

Cite this