M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site

Yota Sato, Taku Fujimura, Sadanori Furudate, Aya Kakizaki, Osamu Iizawa, Setsuya Aiba

Research output: Contribution to journalArticle

Abstract

Since bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis, lupus vulgaris (LV) is reported as one of the rare complications after BCG vaccination, correlating with immunosuppression in the lesional skin. In this report, we describe a case of LV arising from the BCG vaccination site 22 years after vaccination. Interestingly, in the present case, granuloma cells were composed of M2-polarized macrophages. Our case might explain the contribution of M2-polarized macrophages to the biology of LV arising from a BCG vaccination site.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalCase Reports in Dermatology
Volume8
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Bacillus Calmette-Guérin
  • Immunosuppression
  • Lupus vulgaris
  • M2-polarized macrophages

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'M2-Polarized Macrophages Compose Lupus Vulgaris Arising from a Bacillus Calmette-Guérin Vaccination Site'. Together they form a unique fingerprint.

  • Cite this