Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie- associated prion protein accumulation

Katsumi Doh-Ura, Toru Iwaki, Byron Caughey

Research output: Contribution to journalArticlepeer-review

288 Citations (Scopus)

Abstract

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with prion protein molecules. The findings introduce two new classes of inhibitors of the formation of protease-resistant prion protein.

Original languageEnglish
Pages (from-to)4894-4897
Number of pages4
JournalJournal of virology
Volume74
Issue number10
DOIs
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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