Lysosome-Related Organelles

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2 Citations (Scopus)

    Abstract

    Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.

    Original languageEnglish
    Title of host publicationOrganizational Cell Biology
    PublisherElsevier Inc.
    Pages235-242
    Number of pages8
    Volume2
    ISBN (Electronic)9780123944474
    ISBN (Print)9780123947963
    DOIs
    Publication statusPublished - 2016

    Keywords

    • BLOC complex
    • Chédiak-Higashi syndrome
    • Dense granule
    • Griscelli syndrome
    • Hermansky-Pudlak syndrome
    • Lamellar body
    • Lysosome-related organelle
    • Lytic granule
    • MHC class II compartment
    • Melanosome
    • Membrane traffic
    • Secretory lysosome
    • Small GTPase Rab
    • Weibel-Palade body
    • α Granule

    ASJC Scopus subject areas

    • Medicine(all)

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