Lysosome-Related Organelles

M. Fukuda

doi:10.1016/B978-0-12-394447-4.20020-5

Lysosome-Related Organelles

M. Fukuda

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.

Original language	English
Title of host publication	Organizational Cell Biology
Publisher	Elsevier Inc.
Pages	235-242
Number of pages	8
Volume	2
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.20020-5
Publication status	Published - 2016

Keywords

BLOC complex
Chédiak-Higashi syndrome
Dense granule
Griscelli syndrome
Hermansky-Pudlak syndrome
Lamellar body
Lysosome-related organelle
Lytic granule
MHC class II compartment
Melanosome
Membrane traffic
Secretory lysosome
Small GTPase Rab
Weibel-Palade body
α Granule

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-394447-4.20020-5

Cite this

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title = "Lysosome-Related Organelles",

abstract = "Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.",

keywords = "BLOC complex, Ch{\'e}diak-Higashi syndrome, Dense granule, Griscelli syndrome, Hermansky-Pudlak syndrome, Lamellar body, Lysosome-related organelle, Lytic granule, MHC class II compartment, Melanosome, Membrane traffic, Secretory lysosome, Small GTPase Rab, Weibel-Palade body, α Granule",

author = "M. Fukuda",

year = "2016",

doi = "10.1016/B978-0-12-394447-4.20020-5",

language = "English",

isbn = "9780123947963",

volume = "2",

pages = "235--242",

booktitle = "Organizational Cell Biology",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Lysosome-Related Organelles

AU - Fukuda, M.

PY - 2016

Y1 - 2016

N2 - Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.

AB - Lysosome-related organelles (LROs) are a group of cell-type-specific membrane compartments in metazoans that share several features, including low pH and certain luminal contents, with lysosomes. Despite sharing features with lysosomes, the LROs of higher animals are highly specialized in terms of their morphology and composition, and they perform specialized functions, including pigmentation, hemostasis, immunity, and lung plasticity. Because of their importance in biological activities, defects in the biogenesis and/or transport of LROs are known to cause human genetic diseases, including Griscelli syndrome (GS) and Hermansky-Pudlak syndrome (HPS), which are characterized by hypopigmentation of hair and skin, delayed blood clotting, immunodeficiency, and/or pulmonary fibrosis.

KW - BLOC complex

KW - Chédiak-Higashi syndrome

KW - Dense granule

KW - Griscelli syndrome

KW - Hermansky-Pudlak syndrome

KW - Lamellar body

KW - Lysosome-related organelle

KW - Lytic granule

KW - MHC class II compartment

KW - Melanosome

KW - Membrane traffic

KW - Secretory lysosome

KW - Small GTPase Rab

KW - Weibel-Palade body

KW - α Granule

UR - http://www.scopus.com/inward/record.url?scp=85042768566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042768566&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394447-4.20020-5

DO - 10.1016/B978-0-12-394447-4.20020-5

M3 - Chapter

AN - SCOPUS:85042768566

SN - 9780123947963

VL - 2

SP - 235

EP - 242

BT - Organizational Cell Biology

PB - Elsevier Inc.

ER -

Lysosome-Related Organelles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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