Lysophospholipids in laboratory medicine

Yutaka Yatomi, Makoto Kurano, Hitoshi Ikeda, Koji Igarashi, Kuniyuki Kano, Junken Aoki

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Lysophospholipids (LPLs), such as lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and lysophosphatidylserine (LysoPS), are attracting attention as secondgeneration lipid mediators. In our laboratory, the functional roles of these lipid mediators and the mechanisms by which the levels of these mediators are regulated in vivo have been studied. Based on these studies, the clinical introduction of assays for LPLs and related proteins has been pursued and will be described in this review. Although assays of these lipids themselves are possible, autotaxin (ATX), apolipoprotein M (ApoM), and phosphatidylserine-specific phospholipase A1 (PS-PLA1) are more promising as alternate biomarkers for LPA, S1P, and LysoPS, respectively. Presently, ATX, which produces LPA through its lysophospholipase D activity, has been shown to be a useful laboratory test for the diagnosis and staging of liver fibrosis, whereas PS-PLA1 and ApoM are considered to be promising clinical markers reflecting the in vivo actions induced by LysoPS and S1P.

Original languageEnglish
Pages (from-to)373-389
Number of pages17
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume94
Issue number10
DOIs
Publication statusPublished - 2018

Keywords

  • Apolipoprotein M
  • Autotaxin
  • Lysophosphatidic acid
  • Lysophosphatidylserine
  • Lysophospholipids
  • Sphingosine 1-phosphate

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

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